Seager had four hits and Taylor Trammell also homered for Seattle, which trailed 6-0 going into the sixth. The Mariners won a road series for the first time since Sept. 11-13, 2019, at Arizona.
Byron Buxton continued his early season success with a homer, double and single and Luis Arraez had a pair of hits for the Twins.
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The Mariners trailed 6-5 going into the ninth. Mitch Haniger and Ty France opened the inning with singles against Alex Colomé and Seager followed with his homer.
Colomé (0-1) blew a save for the second time in four chances.
Drew Steckenrider (1-1) pitched a scoreless eighth before Rafael Montero earned his second save in four chances with a 1-2-3 ninth.
Buxton has eight hits in three games to increase his batting average to .500. His 1.231 slugging percentage is tops in the majors.
Up 1-0, Minnesota scored three runs in the third inning, two on a bases-loaded double the opposite way by Buxton, who has a hit in all eight games he’s played. He has at least one extra-base hit in seven of them.
Buxton added a towering 428-foot two-run home run to the bullpen in the fifth for a 6-0 lead and led to some in the crowd to chant “MVP!”
Minnesota starter Matt Shoemaker scattered three hits in five innings before falling apart in the sixth.
Seager hit a leadoff homer and Trammell launched a three-run shot for his second in as many days. As the ball was on its way beyond the right-field seats, Shoemaker had words for home plate umpire Manny Gonzalez and was ejected.
Seattle added one run in the seventh.
Against a Twins team averaging 6.1 runs per game, Seattle starter Chris Flexen allowed six runs — five earned— in five innings. He struck out seven.
GETTING HEATED
Buxton was hit in the shoulder by a pitch from Will Vest in the seventh and both benches were warned. Seattle manager Scott Servais protested and was ejected.
France was hit on an up-and-in fastball from Cody Stashak in the top of the frame. France was also hit in the first.
TRAINERS ROOM
Mariners: 1B Evan White entered as a defensive replacement in the ninth. He missed the past two games with left quad tightness.
Twins: 3B Josh Donaldson (mild right hamstring strain), who is eligible to come off the injured list Monday, went through a Sunday workout at the team’s alternate training site. … On the DL since April 7, OF Brent Rooker (cervical strain) is ready to start doing some work at the team’s alternate site.
UP NEXT
Mariners: LHP Justin Sheffield (0-1, 7.20) is to open a four-game series Monday in Baltimore against Orioles RHP Dean Kremer (0-1, 9.00).
Twins: Open a four-game series Monday at Target Field against Boston with LHP J.A. Happ (0-0, 2.25) facing LHP Martín Pérez (0-0, 5.40) of the Red Sox.
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